Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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Quantity
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226
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240
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226
Tocris Bioscience™ TBK1 PROTAC™ 3i
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Potent TANK-binding kinase 1 (TBK1) PROTAC™
227
Tocris Bioscience™ DMSO, sterile filtered
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Solvent for polar and nonpolar compounds
228
Tocris Bioscience™ Veliparib dihydrochloride
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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High affinity PARP-1 and -2 inhibitor; orally bioavailable
229
Tocris Bioscience™ FTBMT
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Potent and selective GPR52 agonist; orally bioavailable and BBB permeable
| CAS | 1358575-02-6 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 4-[3-[[3-Fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methylbenzamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C19H16F4N4O |
| Formula Weight | 392.35 |
230
| CAS | 19685-09-7 |
|---|---|
| Molecular Formula | C20H16N2O5 |
231
| Target | Voltage-gated Potassium Channel Activators |
|---|---|
| CAS | 339287-36-4 |
| Purity | 0.98 |
| Chemical Name or Material | N-(1,2-Dihydro-5-acenaphthylenyl)-4-fluorobenzamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C19H14FNO |
232
Tocris Bioscience™ Lapatinib
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor (IC50 values are 9.8 and 10.2 nM, respectively)
| CAS | 231277-92-2 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C29H26ClFN4O4S |
| Formula Weight | 581.06 |
233
Tocris Bioscience™ ALDH Detection Reagent - BAAA-DA
Fluorescent ALDH substrate and detection reagent. Used for: identification of cells with high ALDH activity. Application: flow cytometry, fluorescent-activated cell sorting (FACS)
234
Tocris Bioscience™ PFI 7
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and Specialty Supplier Partner
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Selective GID4 antagonist
| Target | Ubiquitin Ligase (E3) Inhibitors |
|---|---|
| Purity | 0.98 |
| Chemical Name or Material | N-((1s,4s)-4-(1H-Benzo[d]imidazol-2-yl)cyclohexyl)-2-(((1H-indol-2-yl)methyl)amino)acetamide dihydrochloride |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C24H27N5O.2HCl |
235
Tocris Bioscience™ VH 032
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Inhibitor of VHL; blocks interaction of VHL and HIF-α
| Target | Von Hippel Lindau |
|---|---|
| CAS | 1448188-62-2 |
| Purity | 0.98 |
| Chemical Name or Material | (2 S,4 R)-1-(-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C24H32N4O4S |
236
Tocris Bioscience™ CMA
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Murine-selective STING agonist
| Target | STING Agonists |
|---|---|
| CAS | 38609-97-1 |
| Purity | 98% |
| Chemical Name or Material | 9-Oxo-10(9H)-acridineacetic acid |
| Recommended Storage | Store at 4°C |
| Synonym | ERIS, hMITA, MITA, mitochondrial mediator of IRF3 activation, MPYS, NET23, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, sting, transmembrane protein 173 |
| Molecular Formula | C15H11NO3 |
| Formula Weight | 253.25 |
237
Tocris Bioscience™ TL 13-27
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Negative control for TL 12-186
238
R&D Systems™ Cy5 Labeled Heparan Sulfate Proteoglycan (Cy5-HSPG)
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Used as a substrate to study activity of various heparanases and heparinases and protein heparan sulfate interactions
239
Tocris Bioscience™ JT010
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Potent and selective TRPA1 channel activator (EC50 = 65 nM)
| CAS | 917562-33-5 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C16H19ClN2O3S |
| Formula Weight | 354.85 |
240
Tocris Bioscience™ HHP 9
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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BET bromodomain Degrader (PROTAC™); also potent Hedgehog pathway inhibitor